摘要
Abstract
TGF-beta1/Smad signaling pathway is one of the important pathways in development of renal interstitial fibrosis. As the re-search of molecular biology and Chinese medicine pharmacology,traditional Chinese medicine has displayed a wide range of pharmaco-logical effects in regulating the TGF-beta/ Smad signaling pathways antagonism renal interstitial fibrosis. Regardless of traditional Chi-nese medicine(TCM)monotherapy or traditional Chinese medicine compound and its effective ingredients,performance for:direct inhi-bition of TGF-beta1,or inhibition TGF-beta1 stimulating downstream factor CTGF,or inhibitory Smads phosphorylation,or regulating the expression of TβR and Smad,which show TGF-beta1/Smads pathway and the regulation effect of the signaling proteins through multi-channel,multi-level and multiple targets. But due to the complex traditional Chinese medicine compound composition,should be more fully discuss the TGF-beta/ Smad signaling pathways of each link,different targets and regulatory mechanism of interaction with other signaling pathways,and through research,effective parts selection,effective component analysis and so on,clarify the coordinating role between drugs further,to filter out the basis of clinical curative effect is reliable non-toxic side effects and its clinical drug best compati-bility dose or form,this is one of the best breakthrough point of a traditional Chinese medicine compound study.关键词
TGF-β1/Smad/信号通路/肾间质纤维化/中药单方/复方中药Key words
TGF-beta1/Smad/signaling pathway/renal interstitial fibrosis/traditional Chinese medicine single drug/compound tradi-tional Chinese medicine分类
医药卫生
