中医学报Issue(12)：1724-1726,3.
丹参多酚酸盐对糖尿病周围神经病变患者炎性细胞因子及周围神经传导速度的影响
Effect of Salvianolate on Inflammatory Cytokines and Nerve Conduction Velocity in Diabetic Peripheral Neuropathy Patients
摘要
Abstract
Objective:To investigate the effect of salvianolate on inflammatory cytokines and nerve conduction velocity in diabetic periph-eral neuropathy patients. Methods:80 patients with diabetic peripheral neuropathy were randomly divided into the experimental group and the control groups,40 patients in each group. The control group of patients received insulin therapy,The experimental group were treated with salvianolate based on the control group. The levels of serum soluble intercellular adhesion molecule-1(sICAM-1),interleu-kin-6(IL-6),nitric oxide(NO),endothelin-1(ET-1),tumor necrosis factor-α(TNF-α)were detected before and after treatment. The level of limb nerve conduction velocity(MNCV)and sensory conduction velocity(SNCV)were measured before and after treatment. Re-sults:The levels of serum soluble intercellular adhesion molecule-1(sICAM-1),interleukin-6(IL-6),endothelin-1(ET-1),tumor necro-sis factor-α(TNF-α)were higher after treatment compared with before treatment(P < 0. 05). The level of nitric oxide(NO)was lower after treatment compared with before treatment(P < 0. 05). The levels of limb nerve conduction velocity(MNCV)and sensory conduc-tion velocity(SNCV)were higher after treatment compared with before treatment(P < 0. 05). Conclusion:Salvianolate could effectively reduce the inflammation reaction and improve the nerve conduction velocity and clinical outcomes.关键词
糖尿病周围神经病变/丹参多酚酸盐/炎性细胞因子/周围神经传导速度Key words
diabetic peripheral neuropathy/salvianolate/inflammatory cytokines/the nerve conduction velocity分类
医药卫生引用本文复制引用
赵琳..丹参多酚酸盐对糖尿病周围神经病变患者炎性细胞因子及周围神经传导速度的影响[J].中医学报,2014,(12):1724-1726,3.基金项目
北京市卫生局2012年度重点扶持计划 （）
