中医学报Issue(12)：1778-1779,1782,3.
心脑宁片对脾脏组织的影响
Effect of Xinnaoning Tablets on Spleen Tissue
摘要
Abstract
Objective:To observe the effect of Xinnaoning tablets on D-galactose subacute aging model mice spleen tissue. Methods:72 mice were randomly divided into 6 groups,12 rats in each group(male and female),of which one group as control group,daily subcuta-neous injection of the same volume of physiological saline;the other 5 groups(model group,Nao'an tablet group,large dose group of Xinnaoning piece,middle dose group,small dose group)production the subacute aging model induced by D-galactose,daily subcutane-ous injection of D-galactose(saline match 5% ,injection volume was 0. 025 mL·g - 1 )the production of glucose metabolism in aging model,daily injection of one,continuous 40 days. From the beginning of the eleventh day,Xinnaoning large dose group,medium dose group,low dose group were intragastrically Xinnaoning tablets suspension(2. 24 g·kg - 1 ,1. 12 g·kg - 1 ,0. 56 g·kg - 1 ,112 g·L - 1 , 56 g·L - 1 ,28 g·L - 1 ,equivalent to the clinical doses of 30,15,7. 5 times),Nao'an tablets suspension(0. 53 g·kg - 1 ,26. 5 g· L - 1 ,0. 02 mL·g - 1 ,15 times equivalent to the clinical dosage)and saline of the same volume;blank control group saline perfusion of the same volume. On the fortieth day after medication,measuring the size of spleen nodules,lymphocyte count,and the changes were ob-served under the light microscope splenic tissue morphology. Results:compared with the model group,high dose group of Xinnaoning piece,middle dose group and Nao'an tablets group significantly increased the number of spleen lymphocyte(P < 0. 01),on the splenic nodules,only increasing trend;Xinnaoning piece of high dose,middle dose group of lymphoid cells in the spleen of mouse D-galactose aging model to increase the number of role optimal. Conclusion:Xinnaoning tablets has the improving effect on D-galactose subacute ag-ing model mice spleen tissue.关键词
心脑宁片/脾脏组织/脑安片/小鼠Key words
xinnaoning tablets/spleen tissue/nao'an tablets/mice分类
医药卫生引用本文复制引用
吕宏迪,王灵,郝少君,张正臣..心脑宁片对脾脏组织的影响[J].中医学报,2014,(12):1778-1779,1782,3.基金项目
河南省科技发展计划项目 （）
