中医学报Issue(4)：539-541,3.DOI:10.16368/j.issn.1674-8999.2015.04.186
制马钱子对佐剂性关节炎大鼠抗炎作用的实验研究
Experimental Study of Processing Semen Strychni on the Effect of Anti-Inflammatory in Adjuvant Arthritis Rats
摘要
Abstract
Object:To observe the influnce of processing semen strychni on anti-inflammatory effect of adjuvant arthritis rats and explore the mechanism. Methods:48 SD rats were randomly dividided into normal group,model group,tripterygium glycosides group,low dosage of processing semen strychni group,media dosage of processing semen strychni group and high dosage of processing semen strychni group. 15 days,21 days,29 days later,Measuring the rats'emetapodium volume swelling degree and observe generally condition of rats. After the experiment,the cytokines level of NO and NOS from the rats'serum was detected. Results:Processing semen strychni can effec-tively inhibit the rat foot swelling degrees(P<0. 05). In tripterygium wilfordii glycosides group,media dosage of processing semen strychni group and high dosage of processing semen strychni group were lower than that of model group of rats serum NO content,statis-tically significant difference(P<0. 05). media dosage of processing semen strychni group and high dosage of processing semen strychni group were lower than that of low dosage of processing semen strychni group of rats serum NO content,statistically significant difference (P<0. 05). Serum NOS content in tripterygium wilfordii glycosides group,media dosage of processing semen strychni group and high dosage of processing semen strychni group were lower than that of model group(P<0. 05). . Conclusions:This subject proves that pro-cessing semen strychni can reduce the level of NO,NOS in the rats'serum. The mechanism is probably that it regulate the immune disor-der of RA.关键词
制马钱子/佐剂性关节炎/大鼠/抗炎作用Key words
processing semen strychni/adjuvant arthritis/rat/anti-inflammatory effect分类
医药卫生引用本文复制引用
张董喆,孙曙光,李伟,郑福增..制马钱子对佐剂性关节炎大鼠抗炎作用的实验研究[J].中医学报,2015,(4):539-541,3.基金项目
河南省教育厅科学技术研究重点项目（12A360014）；河南中医学院博士科研基金 （）
