中医学报Issue(4)：582-585,4.DOI:10.16368/j.issn.1674-8999.2015.04.200
凝血因子IIIA 亚基Glu651 Gln和Pro564 Leu多态性与冠状动脉粥样硬化性心脏病的关系研究
Study on the Relationship Between the Glu651 Gln and Pro564 Leu Polymorphisms of FXIIIA Gene and Coronary Heart Disease
摘要
Abstract
Objective:To investigate the Glu651Gln and Pro564Leu polymorphisms of FXIIIA gene and coronary heart disease. Methods:The Glu651Gln and Pro564Leu polymorphisms were detected by allele-specific polymerase chain reaction and nucleotide sequencing in the 154 normal controls and 114 coronary heart disease patients. Results:In normal controls,the frequencies of genotype GG,GC and CC of Glu651Gln polymorphism were 0. 754,0. 192,0. 054 respectively and the frequencies of genotypes CC,CT and TT of Pro564Leu poly-morphism were 0. 409,0. 429,0. 162 respectively. The allelic frequencies of the FXIIIA 651Glu,651Gln,564Pro and 564Leu were 0. 838,0. 162,0. 614 and 0. 386 respectively in the normal controls. In patients of coronary heart disease,the frequencies of genotype GG,GC and CC of Glu651Gln polymorphism were 0. 728,0. 219,0. 053 respectively and the frequencies of genotypes CC,CT and TT of Pro564Leu polymorphism were 0. 421,0. 386,0. 193 respectively. The allelic frequencies of the FXIIIA 651Glu,651Gln,564Pro and 564Leu were 0. 838,0. 162,0. 614 and 0. 386 respectively in the Group of coronary heart disease. The frequencies of alleles and geno- <br> type distribution of the FXIIIA Glu651Gln,Pro564Leu were not significant differences between control group and coronary heart disease group(P>0. 05). Conclusion:There are Glu651Gln and Pro564Leu polymorphisms of FXIIIA gene in normal controls and coronary heart disease patients. The two polymorphisms were not associated with coronary heart disease.关键词
凝血因子XIII/冠状动脉粥样硬化性心脏病/血瘀证Key words
coagulation factor XIII/coronary heart disease/stagnation of blood syndrome分类
医药卫生引用本文复制引用
马秋玲,张淑娟,牛喜伟,杜坡洋..凝血因子IIIA 亚基Glu651 Gln和Pro564 Leu多态性与冠状动脉粥样硬化性心脏病的关系研究[J].中医学报,2015,(4):582-585,4.基金项目
国家自然科学基金项目（30060037）；河南省教育厅科学技术研究重点项目 （）
