中医学报Issue(5)：731-733,3.DOI:10.16368/j.issn.1674-8999.2015.05.252
中药保留灌肠治疗溃疡性结肠炎临床研究
Clinical Research on Retention Enema of Traditional Chinese on Serum Levels of Inflammatory Factors of Ulcerative Colitis Patients
摘要
Abstract
Objective:To investigate Influence of retention enema of traditional Chinese medicine on serum levels of inflammatory factors of ulcerative colitis patients.Methods:102 cases of ulcerative colitis patients were randomly divided into control group(n=51)and ob-servation group (n=51).The control group was treated with Sulfasalazine,1.5 -2.0 g each time and 3 times a day.The observation group received retention enema of traditional Chinese medicine for 4 courses and 15 days as a course.Serum TNF-αand IL-6 levels were detected using double antibody sandwich enzyme linked immunosorbent assay (ELISA).Clinical symptoms such as abdominal pain,diarrhea,mucous stool with pus and blood,tenesmus signs of two groups were analyzed.Clinical curative effects of two groups were analyzed by colonoscopy.Results:Before treatment,there was no difference of serum TNF- alpha and IL-6 levels in two groups (P>0. 05).After treatment,serum TNF-and IL-6 levels of two groups decreased significantly compared with before treatment(P<0.05). Serum TNF-αand IL-6 levels in the observation group decreased more significantly than that of the control group(P<0.05 ).After treatment,Clinical symptoms in the two groups improved significantly(P<0.05).And the observation group improved more significant-ly than the control group(P<0.05).The total effective rate of the two groups was 84.31%and 96.08%.The total effective rate of ob-servation group was higher than that of control group(P<0.05).Conclusion:Retention enema of traditional Chinese medicine can sig-nificantly inhibit the levels of inflammatory factors in patients with ulcerative colitis and has significant clinical efficacy.关键词
中药保留灌肠/溃疡性结肠炎/肿瘤坏死因子-α/白介素-6Key words
retention enema of traditional Chinese medicine/ulcerative colitis/tumor necrosis factor-α/interleukin-6分类
医药卫生引用本文复制引用
陈建科..中药保留灌肠治疗溃疡性结肠炎临床研究[J].中医学报,2015,(5):731-733,3.基金项目
河南省教育厅自然科学研究计划项目 （）
