化工进展Issue(7)：1839-1843,1870,6.DOI:10.3969/j.issn.1000-6613.2014.07.031
化学酶法合成盐酸度洛西汀的研究进展
Research progresses in chemoenzymatic synthesis of Duloxetine hydrochloride
李龙 1邱贵森 2蒋泰龙 2曾聪明 2姚其正1
作者信息
- 1. 中国药科大学药学院，江苏 南京 210009
- 2. 上海艾美晶生物科技有限公司，上海 201203
- 折叠
摘要
Abstract
The incidence of depression showed a clear upward trend in the global. Duloxetine is the better antidepressant drugs,there are some disadvantages on the industry for the full chemical synthesis. Enzyme catalysis has mild reaction condition,environmental friendly and synthetic chiral compounds with high enantioselectivity. Introduction of enzymatic can make up for the chemical synthesis. A review of the progress made in this article,we focused on the enzymatic resolution and bio-catalytic asymmetric synthesis critical enantiomer : 1-(tetrahydrothioph-en-2-yl)propan-1-ol derivatives. Meanwhile we summarized their advantages and disadvantages and saw the rosy application prospect. Point out that screening high catalytic and high stability of microorganisms is the main direction of enzymatic technology to achieve industrial application.关键词
盐酸度洛西汀/生物催化/酶法拆分/生物催化不对称合成Key words
Duloxetine hydrochloride/bio-catalysis/enzyme resolution/asymmetry synthesis with biocatalysis分类
化学化工引用本文复制引用
李龙,邱贵森,蒋泰龙,曾聪明,姚其正..化学酶法合成盐酸度洛西汀的研究进展[J].化工进展,2014,(7):1839-1843,1870,6.
