化工进展Issue(11)：3061-3066,6.DOI:10.3969/j.issn.1000-6613.2014.11.038
微通道中环己酮氧化合成ε-己内酯的连续流工艺
Continuous synthesis process ofε-caprolactone from oxidization of cyclohexanone in micro-channel reactor
严生虎 1韩玲玲 1沈卫 2沈介发 1刘建武 1张跃1
作者信息
- 1. 常州大学化工设计研究院，江苏 常州 213164
- 2. 康宁中国 上海 管理有限公司，上海 200040
- 折叠
摘要
Abstract
Peracetic acid was prepared as an oxidant from acetic anhydride and H2O2 firstly,and thenε-caprolactone was synthesized by Baeyer-Villiger oxidization of cyclohexanone in a continuous flow micro-channel reactor. The effects of reactants molar ratio,reaction temperature and residence time on reactant conversion and product yield were investigated for both preparation of peracetic acid and synthesis ofε-caprolactone,and the process conditions were optimized. Under conditions of n(acetic anhydride) ∶n(H2O2)=1.2∶1,reaction temperature at 70℃,residence time of 115s,conversion of H2O2 reached 88.9% and yield of peracetic acid reached 86.7%. Under conditions of n(peracetic acid) ∶n(cyclohexanone)=1.1∶1,reaction temperature at 90℃,residence time of 90s,conversion of cyclohexanone reached 96.2% and yield of ε-caprolactone reached 80.9%. Comparing with the traditional batch reaction process,the selectivities and yields of target products in this continuous micro-channel reaction process were increased with shortened reaction time and lessened raw material consumption,and process continuity ensured higher operation safety.关键词
微通道反应器/环己酮/ε-己内酯/Baeyer-Villiger氧化Key words
micro-channel reactor/cyclohexanone/ε-caprolactone/Baeyer-Villiger oxidation分类
化学化工引用本文复制引用
严生虎,韩玲玲,沈卫,沈介发,刘建武,张跃..微通道中环己酮氧化合成ε-己内酯的连续流工艺[J].化工进展,2014,(11):3061-3066,6.
