化工进展Issue(1)：173-177,223,6.DOI:10.16085/j.issn.1000-6613.2015.01.030
pH值响应聚乙二醇化壳聚糖基隐形纳米胶束的制备及其载药性能
pH-responsive PEGylated nanoparticles based on dilauryl chitosan:Preparation,physicochemical characterization and in vitro evaluation
摘要
Abstract
Through acylation reaction , a novel chitosan amphiphilic derivative , N,N-dilauryl-3,6-O-mPEG-chitosan (PEDLCS) with high degree of grafting was synthesized by grafting mPEG-COOH onto N,N-dilauryl chitosan. The product was characterized with 1H NMR,FTIR,and EA. KP-loaded PEDLCS micelles were prepared by dialysis. PEDLCS could form micelles via self-assembly in aqueous solution and the CMC value of PEDLCS was 0.1170 mg/mL. The drug loading content and efficiency of KP-loaded PEDLCS micelles were determined as 34.48% and 65.78% respectively under the optimal ratio of KP and PEDLCS (0.8∶1). The KP-loaded PEDLCS micelles had average size of 155.1nm and zeta potential of−31.6 mV. The response experiments about drug-loaded micelle under the conditions of different pH values showed that stability of the micelles decreased and diameter of the micelles increased with decreasing pH value,and the process was reversible. The range of pH response rightly agreed with the growth microenvironment of tumor cell (pH7.2—6.0). It would be expected to become a new material of drug delivery system.关键词
两亲性壳聚糖/聚乙二醇单甲醚/pH值响应性/自组装胶束Key words
amphiphilic chitosan/mPEG/pH-responsive/self-assembly micelles分类
化学化工引用本文复制引用
姚文杰,辛梅华,李明春,方江海..pH值响应聚乙二醇化壳聚糖基隐形纳米胶束的制备及其载药性能[J].化工进展,2015,(1):173-177,223,6.基金项目
福建省重点科技项目（2009H0030）、福建省自然科学基金（2011J01312和2012J01396）及科技部科技人员服务企业（2009GJC40030）项目。 （）
