化工进展Issue(1)：188-192,233,6.DOI:10.16085/j.issn.1000-6613.2015.01.033
海因改性N-季铵化壳聚糖衍生物的合成及其抗菌性能
Synthesis and antibacterial research of hydantoin modified quaternary ammonium chitosan
摘要
Abstract
Under acidic condition,N-(2-hydroxy)propyl-3-trimethyl ammonium chloride chitosan (HTCC) was synthesized by reaction of chitosan and glycidy quaternized salts. Then 3-glycidy-5,5-dimethyl hydantoin (made in our lab) was used to synthesize O-hydroxy-propyl (5,5-dimethyl hydantoin)-N-(2-hydroxy)propyl-3-trimethyl ammonium chloride chitosan (GH-HTCC). The products were confirmed by FTIR,1H NMR,UV-VIS,EA. The results of antibacterial tests indicated antibacterial activity of these products with better antimicrobial activity against S. aureus than against E. coil. Antibacterial activity of GH-HTCC was stronger than HTCC and increased as the degree of substitution increased. A lower concentration of EDTA improved antibacterial activity of HTCC and GH-HTCC,but a higher concentration of EDTA inhibited antibacterial activity.关键词
壳聚糖/季铵化/环氧海因/乙二胺四乙酸/抗菌活性Key words
chitosan/quaternized/3-glycidyl-5,5-dimethyl hydantoin/EDTA/antibacterial activity分类
化学化工引用本文复制引用
陈燕燕,李明春,辛梅华,林意华..海因改性N-季铵化壳聚糖衍生物的合成及其抗菌性能[J].化工进展,2015,(1):188-192,233,6.基金项目
福建省重点科技项目（2009H0030）、福建省自然科学基金（2011J01312和2012J01396）及科技部科技人员服务企业项目（2009GJC40030）。 （）
