化工进展Issue(7)：1951-1955,5.DOI:10.16085/j.issn.1000-6613.2015.07.023
壳聚糖基聚电解质复合膜的制备及性能
Preparation and properties of polyelectrolyte composite films based on chitosan
摘要
Abstract
In order to overcome the drawbacks of poor mechanical strength and too fast degradation of chitosan films,poly(lactic acid-co- malic acid) (PML) was prepared by an “one-step” method,and the carboxyl content and hydrophobicity of the copolymers could be adjusted by changing the molar ratio in feed. The copolymers were added to chitosan for complexation in aqueous solutions,and the modified complex films were prepared via a casting/solvent evaporation technique. The composite films were characterized by FT-IR and TGA,and their mechanical properties,degradation and vitro cytotoxicity were investigated. The influence of molar ratio between MA and LA in feed on the structure and properties of the films were studied. The results showed that in the molar ratio of nMA∶nLA= 1∶1.5,the tensile strength of the film is 54.8MPa,breaking elongation is 10.7%,mass loss is 50% after 28 days and the 3T3 cell viability profiles are 98.7%. It is concluded that the composite film can be formed by polyelectrolyte interaction between chitosan and PML. The flexibility of the composite film is improved and degradation time is extended compared to pure chitosan film. The film properties can be adjusted by changing components in the copolymers. The composite films are non-cytotoxic,biocompatible,and have potential applications as tissue adhesion prevention materials.关键词
壳聚糖/聚(苹果酸-co-乳酸)/聚电解质复合膜/防粘连Key words
chitosan/poly(lactic acid-co-malic acid)/polyelectrolyte composite film/adhesion prevention分类
化学化工引用本文复制引用
陶蕾,石刚,倪才华..壳聚糖基聚电解质复合膜的制备及性能[J].化工进展,2015,(7):1951-1955,5.基金项目
江苏省科技支撑计划－工业部分（BE2012017）及国家自然科学基金（21401079）项目。 （）
