化工学报Issue(6)：2357-2362,6.DOI:10.3969/j.issn.0438-1157.2014.06.055
改性聚乳酸-聚乙二醇--多西紫杉醇给药系统的制备
Modified polylactic acid loading docetaxel for anticancer drug delivery
摘要
Abstract
Nanoparticles based on poly(2-amino-1, 3-propanediol carbonic ester-co-lactide) -g- PEG(P(LA-co-CA)-mPEG) were prepared by using the emulsion solvent diffusion method. The copolymer of P (LA-co-CA) was prepared by using ring-opening polymerization with diethylzinc (ZnEt2) as initiator, and then benzyl oxygen group was taken off to obtain P (LA-co-CA). With the anticancer drug, docetaxel (DTX), as a model drug, the morphology of nanoparticles was characterized with scanning electron microscopy (SEM) and the size and size distribution were determined by dynamic light scattering (DLS). SEM images and DLS results revealed that the particles were spherical in shape and about 100 nm in size, which was suitable for intravenous injection and close to the typically required size under physiological conditions. Thus, nanoparticles of P (LA-co-CA)-mPEG could be used as biodegradable, biocompatible, and cell-specific targetable nano-structured carriers for intracellular delivery of hydrophobic anticancer drugs.关键词
结晶/合成/纳米粒子/聚乳酸/多西紫杉醇/共聚物Key words
crystallization/synthesis/nanoparticles/polylactide/docetaxel/copolymer分类
化学化工引用本文复制引用
李瑞端,张建军,陈建峰,滕巍,李彩霞,王洁欣..改性聚乳酸-聚乙二醇--多西紫杉醇给药系统的制备[J].化工学报,2014,(6):2357-2362,6.基金项目
国家自然科学基金项目(51303009),国家高技术研究发展计划项目(2013AA032201)。@@@@supported by the National Natural Science Foundation of China (51303009)and the National High Technology Research Development Program of China (2013AA032201) （51303009）
