化工学报Issue(4)：1243-1251,9.DOI:10.11949/j.issn.0438-1157.20141332
代谢控制发酵产琥珀酸研究进展
Research advances in metabolic control of succinic acid fermentation
摘要
Abstract
As an important chemical raw material, succinic acid is widely used in many fields of modern industry with a huge market demand. Recently, the biological method for succinic acid fermentation has become a hot topic in research, since it has the advantages of renewable utilization of resources and environmental friendly production. From the perspective of metabolic control, the methods and strategies for succinic acid production with some strains, especially the recombinant E. coli, are summarized in this paper. Regulation of key enzyme gene in metabolism branch and the key factors in fermentation of succinic acid, such as regulation of redox force, carbon dioxide control, and metabolic pathways transforming are introduced. The progress of metabolic control of succinic acid fermentation is presented, and development of succinic acid fermentation in the future is proposed.关键词
重组大肠杆菌/琥珀酸/生物技术/代谢/发酵/二氧化碳Key words
recombinant E. coli/succinic acid/biotechnology/metabolism/fermentation/carbon dioxide分类
生物科学引用本文复制引用
王乐,倪子富,惠明,王金水..代谢控制发酵产琥珀酸研究进展[J].化工学报,2015,(4):1243-1251,9.基金项目
国家自然科学基金项目（21306040）；河南省科技厅自然科学项目（142102210412）；（化工资源有效利用)国家重点实验室项目（ CRE-2014-C-301）；省属高校基本科研业务费专项资金（2014YWQQ17）；河南工业大学校基金项目（2014CX12C06）。of China (21306040), the Natural Science Foundation of Science and Technology Agency Henan Province(142102210412), the (Effective Utilization of Chemical Resources) State Key Laboratory Project (CRE-2014-C-301), the Basic Scientific Research Special Funds of Provincial Col eges and Universities (2014YWQQ17) and Henan University of Technology Fund Projects (2014CX12C06). @@@@supported by the National Natural Science Foundation （21306040）
