核化学与放射化学Issue(3)：129-139,11.DOI:10.7538/hhx.2014.36.03.0129
铀酰与多肽和蛋白质相互作用研究进展
Recent Research Progress of Interactions Between Uranyl Ions and Peptides/Proteins
摘要
Abstract
With the rapid development of nuclear energy industry, the bio-toxicities of actinides have drawn more and more attention with respect to their potential harmful effects on ecological environment and bio-organisms. Studying the interaction mechanisms of actinide cations with biomolecules, especially peptides or proteins, can provide useful information in molecular level for understanding the transportation, absorption and deposition pathways of actinides invivo.Uranium,as a central actinide in nuclear fuel cycle, deserves more research endeavors.In this work,recent progresses about the interaction mechanisms between uranyl (UO2+2 )and amino acids,peptides and proteins are reviewed. The coordination modes,molecular structures and thermodynamic data of UO2+2 -peptide complexes are selectively highlighted.The possible roles of the plasma proteins play in UO2+2 transportation,absorption and deposition are discussed.In addition,the basic principles for designing UO2+2 specific binding peptides and proteins are presented.关键词
铀酰/氨基酸/多肽/蛋白质/相互作用/分子水平Key words
uranyl/amino acid/peptide/protein/interactions/molecular level分类
生物科学引用本文复制引用
刘洋,肖成梁,梅雷,屈国普,石伟群..铀酰与多肽和蛋白质相互作用研究进展[J].核化学与放射化学,2014,(3):129-139,11.基金项目
国家自然科学基金资助项目(11275219) （11275219）
