哈尔滨商业大学学报（自然科学版）Issue(6)：655-658,4.
电子束辐照对黄连有效成分影响的研究
Study on impact of electron beam irradiation on active ingredient of berberine
王强 1张玉宝 1梁宏斌 1斯琴图雅 1蒋继成 1张春静2
作者信息
- 1. 黑龙江省科学院技术物理研究所，哈尔滨150086
- 2. 哈药集团世一堂制药厂，哈尔滨150078
- 折叠
摘要
Abstract
By electron beam irradiation of different doses of berberine herbs, to exam changes in the dissolution rate of the active ingredient, and by HPLC to compare irradiation finger-prints of berberine herbs before and after to determine the impact of radiation on the chemical composition.The results showed that taking 1 MeV, 0.67kGy/s dose rate, 40 kGy dose e-lectron beam irradiation, the active ingredient of berberine herbs significantly increased ( P<0.05).The fingerprint matching similarity was above 0.99, and the chemical composition was stable with no radiation derivatives.Therefore, the electron beam irradiation as a sec-ondary method to extract the active ingredient of berberine hydrochloride is an efficient and convenient process.关键词
电子束辐照/黄连药材/有效成分/稳定性/指纹图谱Key words
electron beam irradiation/berberine herbs/active ingredients/stability/finger-prints分类
医药卫生引用本文复制引用
王强,张玉宝,梁宏斌,斯琴图雅,蒋继成,张春静..电子束辐照对黄连有效成分影响的研究[J].哈尔滨商业大学学报（自然科学版）,2014,(6):655-658,4.
