华南农业大学学报Issue(1)：14-17,4.
中药组方“虎诃紫”的急性毒性试验及对鸡白痢的临床疗效
An acute toxicity test of compound traditional Chinese medicine“Huhezi” and its efficacy in chickens experimentally infected with Salmonella pullorum
摘要
Abstract
[Objective]To investigate the toxicity of compound traditional Chinese medicine “Huhezi” and observe its efficacy in chickens experimentally infected with Salmonella pullorum.[Methods] According to the veterinary drug research technical guidelines , the acute toxicity test was carried out in mice by ga-vage with “Huhezi”extracts.To evaluate the efficacy of “Huhezi” granules,the chickens experimentally infected with Salmonella pullorum were treated at a dosage of 4.20,1.62,0.48 g/d respectively by drink-ing water for 7 successive days .[Result and conclusion] The dose of acute toxicity test of “Huhezi”ex-tracts was over 5 000 mg/kg.No death was observed in mice ,revealing LD50 >5 000 mg/kg.The maxi-mum tolerated dose was 40 g/kg.The cure rates of different dose granules groups were 75.0%,72.7%, 62.5%and the effective rates were 83.3%,81.8%,75.0%respectively , while the mortality rate of in-fected control group was 40%.The result of χ2 test showed that the mortality rate of high and medium dose group of “Huhezi” granule was significanty different from that of the infected control group .The re-sults indicate that compound traditional Chinese medicine extracts are non -toxic, and the high and medi-um dose of “Huhezi” granules have certain protection to infected death of S.pullorum, with cure rates and effective rates of high dose group being higher than that of medium and low dose groups , the mortality rates of high and medium dose groups being lower than that of the infected control groups .关键词
中药组方“虎诃紫”/急性毒性试验/鸡白痢沙门菌/疗效Key words
compound traditional Chinese medicine “Huhezi”/acute toxicity test/Salmonella pullorum/curative effect分类
农业科技引用本文复制引用
代如意,殷中琼,贾仁勇,李莉,李曼,康帅,彭练慈,曲径..中药组方“虎诃紫”的急性毒性试验及对鸡白痢的临床疗效[J].华南农业大学学报,2015,(1):14-17,4.基金项目
“十二五”农村领域国家科技计划项目（2011BAD34B03-4）；四川省青年科技创新研究团队项目 （）
