河南农业科学Issue(5)：146-150,5.
氟甲喹在大菱鲆体内的药代动力学研究
A Pharmacokinetic Study of Flumequine in Scophthalmus maximus
摘要
Abstract
The purpose of this study was to investigate the pharmacokinetics behavior of flumequine,and calculate the dosage regimen of flumequine in Scophthalmus maximus. Six fish were randomly selected from the tank and sampled at 15,30 min and 1,2,4,6,8,12,16,24,36,48,72,96 h after intravenous and oral administration at 20 mg/kg flumequine,respectively,at 14—17 ℃ water temperature. The con-centrations of flumequine were determined by the high performance liquid chromatography. The data were analyzed with the pharmacokinetic program DAS 2 . 0 . The results showed that the apparent distribution volume,the elimination half-life, the area under concentration-time curve and the bioavailability were 5. 46 L/kg,56. 93 h,220. 32 h·mg/L and 100%,respectively,after intravenous administration. After oral administration, the area under concentration-time curve was 95. 85 h·mg/L,the bioavailability was 43. 51%,the time to peak concentration was 16 h,the apparent distribution volume was 4. 21 L/kg,and the elimination half-life was 14. 12 h. The results indicated that an adequate distribution from turbot plas-ma to various tissues after intravenous and oral administration,however,elimination rate was faster by oral administration than by intramuscular administration. According to the flumequine pharmacokinetics and the minimal inhibitory concentration of most fish bacterial pathogens,this study indicates that it is possible to obtain therapeutic flumequine blood concentrations via oral administration in turbot with the dose of 20 mg/kg at the interval of one day.关键词
大菱鲆/氟甲喹/药代动力学/给药方案Key words
Scophthalmus maximus/flumequine/pharmacokinetics/dosage regimen分类
农业科技引用本文复制引用
梁俊平,段亚飞,葛倩倩,李健,聂国兴,孔祥会,常志强..氟甲喹在大菱鲆体内的药代动力学研究[J].河南农业科学,2015,(5):146-150,5.基金项目
中国水产科学研究院基本科研业务费专项(2014A09XK02) （2014A09XK02）
河南省重点科技攻关项目(142102310037) （142102310037）
