华侨大学学报（自然科学版）Issue(3)：316-320,5.DOI:10.11830/ISSN.1000-5013.2014.03.0316
G／11木聚糖酶最适 pH 值的预测及其与氨基酸位置的关系
Prediction of Optimum pH of G/11 Xylanases and the Relationship between the Location of Amino Acid and Optimum pH Value
摘要
Abstract
We divided the xylanase sequences into three equally segments named N-terminus,I-terminus and C-terminus. And then,we calculated the amino acid compositions of the whole sequences and the segmented sequences,respectively. The amino acid compositions were used as the input values of these models.The principal component analysis (PCA) method was utilized to analyze the relationship between the amino acid composition and the optimum pH.The uniform de-sign was used to optimize the running parameters of support vector machines (SVM)and neural network (BPNN),re-spectively.Our results showed the predicted model obtained by SVM was better than that of BPNN,and the SVM model based on RBF kernel was best.The results of PCA showed the correlation between principle component and optimum pH was best in the I-terminus with the R=-0.68,which coincided with the result of the SVM.关键词
木聚糖酶/氨基酸/支持向量机/BP 神经网络/均匀设计/主成分分析Key words
xylanase/amino acid/support vector machine/BP neural network/uniform design/principle component a-nalysis分类
生物科学引用本文复制引用
林源清,张光亚..G／11木聚糖酶最适 pH 值的预测及其与氨基酸位置的关系[J].华侨大学学报（自然科学版）,2014,(3):316-320,5.基金项目
国家自然科学基金资助项目（21376103）；福建省自然科学基金资助项目 （）
