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抗氧化剂阿魏酸自组装金纳米颗粒的体外抗氧化

张晗 李砚超 姜玉刚 杜立波 施维 刘扬

华侨大学学报(自然科学版)Issue(1):60-63,4.
华侨大学学报(自然科学版)Issue(1):60-63,4.DOI:10.11830/ISSN.1000-5013.2015.01.0060

抗氧化剂阿魏酸自组装金纳米颗粒的体外抗氧化

In Vitro Antioxidant Activity Study of Ferulic Acid Self-Assembled Gold Nanoparticles

张晗 1李砚超 2姜玉刚 2杜立波 2施维 1刘扬2

作者信息

  • 1. 吉林大学 分子酶学工程教育部重点实验室,吉林 长春 130012
  • 2. 中国科学院化学研究所 分子动态与稳态结构国家重点实验室,北京 100190
  • 折叠

摘要

Abstract

The antioxidant protection effects of ferulic acid nanoantioxidant on macrophage cells were studied and the free radical-inhibiting activities of ferulic acid nanoantioxidant were determined at the cellular level using electron spin reso-nance-spin trapping and UV-spectrum method.The results illustrates that the nanoantioxidant could eliminate the reactive oxygen species stimulated by t-BuOOH in cells more effectively than that of antioxidants monomers.Meanwhile,the lipid peroxide detection of malondialdehyde by spectrum method also proved that the nanoantioxidant have a high antioxidant activity on t-BuOOH stimulated macrophage cells.Therefore,it could be concluded that the self-assembled nanoantioxi-dant have a potential for the enhancement of antioxidant activity.

关键词

电子自旋共振/抗氧化剂/自旋捕获/纳米金/脂质过氧化

Key words

electron spin resonance/antioxidant/spin trapping/gold nanoparticles/lipid peroxide

分类

数理科学

引用本文复制引用

张晗,李砚超,姜玉刚,杜立波,施维,刘扬..抗氧化剂阿魏酸自组装金纳米颗粒的体外抗氧化[J].华侨大学学报(自然科学版),2015,(1):60-63,4.

基金项目

国家自然科学基金资助项目 ()

华侨大学学报(自然科学版)

OA北大核心CSTPCD

1000-5013

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