华西口腔医学杂志Issue(4)：328-330,3.DOI:10.7518/hxkq.2014.04.003
乙型肝炎病毒X基因在涎腺腺样囊性癌中表达的实验研究
Experimental study on hepatitis B-virus X gene expression in adenoid cystic carcinoma
摘要
Abstract
Objective To explore the expression of hepatitis B-virus X gene (HBX) in adenoid cystic carcinoma (ACC) and determine its clinical significance. Methods Between June 2008 and October 2012, in-hospital patients with salivary gland tumors who were treated at the Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Kunming Medical University, were enrolled to this study. HBeAb-positive patients were defined as those exposed to hepatitis B virus (HBV) or harboring persistent HBV infection regardless of being HBeAg positive or negative. According to the pathological results, all patients were divided into ACC group and control group. Immunohistochemical staining and polymerase chain reaction (PCR) were used to detect HBX expression in ACC group and control group. Results HBX expression was mostly detected in the cytoplasm of ACC cells. Minimal HBX expression was detected in the nucleus. HBX expression was significantly higher in ACC than in Warthin’s tumor. A significant difference was observed between the two groups. Conclusion HBX is expressed in ACC and may be associated with the development of ACC. HBX might serve important functions in the carcinogenesis and development of ACC.关键词
涎腺腺样囊性癌/乙型肝炎病毒/乙型肝炎病毒X基因Key words
adenoid cystic carcinoma/hepatitis B virus/hepatitis B-virus X gene分类
医药卫生引用本文复制引用
谢玲,王卫红,许彪,刘屿..乙型肝炎病毒X基因在涎腺腺样囊性癌中表达的实验研究[J].华西口腔医学杂志,2014,(4):328-330,3.基金项目
云南省科技厅-昆明医科大学联合专项基金资助项目（20-11FB211，2011FB163）；云南省高层次卫生技术人才专项基金资助项目 （）
