海洋科学Issue(11)：36-41,6.DOI:10.11759/hykx20131206003
海洋真菌Neosartorya fischeri 1008F1的次级代谢产物抑菌及抗肿瘤活性的研究
Antimicrobial and antitumor activities of secondary metabolites from a marine fungus Neosartorya fischeri 1008F1
摘要
Abstract
In this study, we determined antimicrobial and antitumor activity of secondary metabolites obtained from a marine fungus Nesartorya fischeri 1008F1. The antimicrobial activity was evaluated by confront culture and growth rate methods. The antitumor activity was evaluated by MTT assays. The extract of fermentation product was isolated through gel (Sephadex LH-20) column chromatography. The results show that the water soluble extract of marine fungus N. fischeri 1008F1 had inhibitory activity against Alternaria solani. The extract of the strain was isolated through gel (Sephadex LH-20) column chromatography and fractions B, C, D, E and F were obtained. At 0.5 mg/mL, the inhibition rates of fractions B, C and D against SGC-7901 cell line were higher than 80%. At 0.5 mg/mL, the inhibition rates of fractions B, C, D, E and F against BEL-7404 cell line were higher than 70%.关键词
海洋真菌Neosartorya fischeri/次级代谢产物/抑菌活性/抗肿瘤活性Key words
marine fungus Neosartorya fischeri/secondary metabolites/antimicrobial activity/antitumor activity分类
生物科学引用本文复制引用
沈硕..海洋真菌Neosartorya fischeri 1008F1的次级代谢产物抑菌及抗肿瘤活性的研究[J].海洋科学,2014,(11):36-41,6.基金项目
青海省科技厅项目(2011-Z-727) （2011-Z-727）
国家自然基金项目(31360445) （31360445）
青海省农林科学院创新基金项目(2011-NKY-01) （2011-NKY-01）
