渔业科学进展Issue(4)：141-144,4.DOI:10.11758/yykxjz.20140421
南极磷虾油软胶囊囊皮配方的设计与优化
Optimization of Formula for Antartic Krill Oil Soft Capsules Shell
摘要
Abstract
Antartic krill oil is rich in astaxanthin and Omega-3 fatty acids such as EPA and DHA therefore can be used as highly profitable diet supplements. Recently soft capsules have been commonly used to contain oil-soluble health-care food, and the optimization of the formula for soft capsule shell is one of the key factors in the product development. In this study we measured the dissolution rate as a parameter to determine the optimal formula for the soft-gelatin capsule shell. We used tartrazine as the indicator and selected 424 nm as the absorption wavelength. We then established a linear regression equation between the concentration of tartrazine and its absorbance. The orthogonal method was employed to test four factors in the formula of soft capsule shell: the ratio of gelatin to glycerol, the ratio of water to gelatin, the percentage of sorbitol, and the percentage of fumaric acid. In each factor three levels were set up and tested. The dissolution rates of various soft-gelatin capsule shells were obtained according to the Noyes-Whitney equation. The results showed that the dissolution rate reached the maximum value when the ratio of water, glycerol and gelatin was 0.8 : 1 : 0.5 and the percentages of sorbitol and fumaric acid were 3% and 0.7% respectively. The verification test also revealed that the dissolution rate of this formula was very close to the maximum dissolution rate in the orthogonal experiment. Our optimized formula will provide important scientific data for the design of Antartic krill oil soft capsules and other oil-soluble soft capsules.关键词
南极磷虾油/软胶囊/囊皮配方/溶出速率Key words
Antartic krill oil/Soft gel/Formula of capsule shell/Dissolution rate分类
农业科技引用本文复制引用
刘建君,冯迪娜,苏学锋,李宣延,刘洋..南极磷虾油软胶囊囊皮配方的设计与优化[J].渔业科学进展,2014,(4):141-144,4.基金项目
国家863高技术研究发展计划项目“南极磷虾快速分离与深加工关键技术”(2011AA090800)资助。 （2011AA090800）
