渔业科学进展2015，Vol.36Issue(2)：113-117,5.DOI:10.11758/yykxjz.20150215
3种磺胺类药物在中国对虾(Fenneropenaeus chinensis)体内的药代动力学特征
Pharmacokinetics of Three Sulfa-Drugs in theFenneropenaeus chinensis
摘要
Abstract
To better understand the use of sulfa drugs in aquaculture, especially in the culture of Fenneropenaeus chinensis, we studied the pharmacokinetics of three sulfa drugs inF chinensis using the high performance liquid chromatography (HPLC). The three selected sulfa drugs were sulfadimidine (SM2), sulfamethoxydiazine (SMD) and sulfadiazine (SD). The water temperature for the experiment was (24.6±2.4)℃. Healthy shrimp received oral administration of the drugs at a dose of 100 mg/kg. The results showed that the hemolymph concentration-time course of SM2,SMD and SD conformed to a two-compartment open model with the first order absorption after oral administration. Major pharmacokinetic parameters such asT1/2β,AUC,Vd,CL,Tmax andCmax were 25.812 h, 34.066 mg/L·h, 94.553 L/kg, 2.608 L/h·kg, 2 h, 1.07 mg/L respectively for SM2, and 46.446 h, 45.39 mg/L·h, 97.207 L/kg, 1.504 L/h·kg, 1 h, 1.17 mg/L for SD, and 66.296 h, 65.917 mg/L·h, 40.015 L/kg, 0.763 L/h·kg, 2 h, 2.00 mg/L for SMD. These suggested that SMD was more widely distributed and absorbed than SM2 and SD inF. chinensis. The elimination half-life showed the order of SM2＜SD＜SMD. The absorbed dose in 72 h had the order of SMD＞SD＞SM2. As for the drug clearance rate, SMD had the fastest rate and SM2 had the slowest rate. Therefore in 72 hours after the oral administration, SMD had the most residues and the SM2 had the least residues inF. chinensis. In another word, SMD had the longest-lasting pesticide effect. Taking no account of other factors such as the cost and side effects, SMD could be the most suitable sulfa drug according to its pharmacokinetic characteristics. The comparison of the elimination half-life showed that SMD had the most enduring efficacy.关键词
磺胺二甲嘧啶/磺胺嘧啶/磺胺对甲氧嘧啶/中国对虾/药代动力学Key words
SM2/SD/SMD/Fenneropenaeus chinensis/Pharmacokinetics分类
农业科技引用本文复制引用
李金宝,常志强,李健,孙铭..3种磺胺类药物在中国对虾(Fenneropenaeus chinensis)体内的药代动力学特征[J].渔业科学进展,2015,36(2):113-117,5.基金项目
国家虾产业技术体系项目(CARS-47)、山东自主创新专项(2013CXC80202)和公益性行业(农业)科研专项(201103034)共同资助 （CARS-47）
