杭州师范大学学报（自然科学版）Issue(4)：370-372,3.DOI:10.3969/j.issn.1674-232X.2014.04.008
硼氢化立体选择性还原制备拉米夫定的研究
On the Stereo-selective Reduction and Preparation of Lamivudine through Borohydride
摘要
Abstract
Basing on the literature about the preparation of nucleoside antiviral drug Lamivudine ,the paper provided a stereo-selective synthetic route by borohydride as the reducing agent . The formed six-membered ring transition state structure effectively inhibited the racemization ,it made the reaction process have the advantages of simple process ,pure product and high yield ,which completely accorded with the usage requirements as the crude drug .关键词
拉米夫定/硼氢化/立体选择/还原/六元环过渡态Key words
Lamivudine/borohydride/stereo-selectivity/reduction/six-membered ring transition state分类
化学化工引用本文复制引用
徐伟明,黄卓豪,李万梅,游金宗,蒋善会,章鹏飞..硼氢化立体选择性还原制备拉米夫定的研究[J].杭州师范大学学报（自然科学版）,2014,(4):370-372,3.基金项目
浙江省自然科学基金项目（Y4100077）；浙江省创新团队项目（2010R50017）；杭州市重大科技项目（20122511A43）． （）
