杭州师范大学学报（自然科学版）Issue(5)：461-466,6.DOI:10.3969/j.issn.1674-232X.2014.05.002
聚硅氧烷衍生的手性伯胺催化不对称aldol 反应的研究
Chiral Primary Amines Derived from Polysiloxane Catalyze Asymmetric Aldol Reaction
摘要
Abstract
A novel method to prepare chiral primary amines with polysiloxane inert long chain is successfully developed , a series of chiral primary amine catalysts derived from polysiloxane are synthesized ,and the asymmetric aldol reaction which is used to catalyze α,α,α-trifluoroacetophenone and acetone is carried out smoothly with these catalysts .The effects of acids ,the structure of the catalysts and solvents on the reaction are investigated .The asymmetric aldol reaction of α,α,α-trifluoroacetophenone and acetone catalyzed by catalyst A and Boc-L-phenylalanine in water phase exhibits excellent yield (94% ) and moderate enantioselectivity (54% ee) .关键词
聚硅氧烷/手性伯胺/aldol反应/不对称催化Key words
polysiloxane/chiral primary amine/aldol reaction/asymmetric catalysis分类
化学化工引用本文复制引用
杨伟,王彩云,黄伟升,郑战江,杨科芳,徐利文..聚硅氧烷衍生的手性伯胺催化不对称aldol 反应的研究[J].杭州师范大学学报（自然科学版）,2014,(5):461-466,6.基金项目
国家自然科学基金项目（51303043；51203037）． （）
