集成技术Issue(4)：75-81,7.
胸腺五肽辅助治疗肺癌对免疫功能影响及其疗效的系统评价
Evaluation of Thymopentin in Adjuvant Therapy for Patients with Lung Cancer:a Meta-analysis of Randomized Trials
摘要
Abstract
To evaluate the effect of thymopentin (TP5) on immune function and curative effect in adjuvant therapy for patients with lung cancer, we searched online for randomized, placebo-controlled trials that using TP5 as an adjuvant therapy with chemotherapy or radiotherapy for patients with lung cancer, and then evaluated the trials that meet criteria with the software RevMan5.3. As a result, 9 trials were included and 784 patients were observed. The meta-analysis shows that there is no signiifcant change between the experimental group and the control group in terms of the curative effect of lung cancer (OR=1.44, 95%CI(0.99, 2.10), P=0.06>0.05). As to the effect of immune function, TP5 altered the CD3+cell level (OR=5.88, 95%CI(2.34, 9.42), P=0.001, CD4+cell level(OR=8.32, 95%CI(5.22, 11.42), P<0.00001), but did not alter the CD8+cell level (OR=-3.12, 95%CI(-9.02, 2.79), P>0.05)which led to a signiifcant change of the CD4+/CD8+ratio(OR=0.38, 95%CI(0.18, 0.59), P=0.0002). To sum up, TP5 altered the CD3+cell level, CD4+cell level and CD4+/CD8+ratio but did not alter the CD3+cell level and curative effect.关键词
胸腺五肽/肺癌/免疫功能/疗效/系统评价Key words
TP5/lung cancer/immune function/curative effect/systematic分类
医药卫生引用本文复制引用
李怡斯,敖舒婷,金言..胸腺五肽辅助治疗肺癌对免疫功能影响及其疗效的系统评价[J].集成技术,2015,(4):75-81,7.基金项目
深圳市科技创新委员会项目(JCYJ20130402113127506，JCYJ20120617115622211)；深圳市海外高层次人才创新创业团队(孔雀团队)(1110140040347265) （JCYJ20130402113127506，JCYJ20120617115622211）
