激光生物学报Issue(1)：68-72,5.DOI:10.3969/j.issn.1007-7146.2015.01.010
胃癌血清的表面增强拉曼光谱研究
The Study of Gastric Cancer Serum on Surface Enhanced Raman Spectroscopy Technology
摘要
Abstract
Surface-enhanced Raman spectroscopy has been extensively studied and applied in cancer diagnosis field.In this paper,gold colloid was prepared as SERS substrate and its enhanced factor was calculated using crystal violet mole-cules as probes,and the SERS spectra of serum of gastric cancer patients and healthy people were detected.The en-hancement effect of SERS spectra of serum using gold colloid as SERS substrate was significant comparing with Raman spectra of serum.The Raman peaks were mainly assigned to amino acid,nucleic acid,and carbohydrate etc.Comparing with the healthy people,the Raman intensities of nucleic acids of gastric cancer patients were higher and that of proteins were lower,which coincided with the conclusion of medical researches.It indicates that SERS is suitable for distinguis-hing gastric carcinoma and provides a promising approach for gastric cancer diagnosis.关键词
表面增强拉曼光谱 (SERS)/胃癌/血清/金溶胶Key words
Surface Enhanced Raman Spectroscopy (SERS)/gastric carcinoma/serum/gold nanoparticle分类
化学化工引用本文复制引用
孟辰,周涵婧,史晓凤,毛伟征,马君..胃癌血清的表面增强拉曼光谱研究[J].激光生物学报,2015,(1):68-72,5.基金项目
山东省自然科学基金项目（BS2013HZ006）；青岛市科技计划基础研究项目（12-1-4-1-（1）-jch，14-2-4-96-jch） （）
