激光生物学报Issue(1)：95-99,5.DOI:10.3969/j.issn.1007-7146.2015.01.015
唇腺炎性病变组织的共聚焦显微拉曼光谱特征研究
Research on the Confocal Raman microspectroscopic Characters of Inflammatory Labial Gland Tissues
摘要
Abstract
Objective:Research the Raman spectra of inflammatory labial gland tissues in order to provide a research-based theoretical foundation for applying Raman spectroscopy to diagnoses the inflammatory labial gland diseases.Methods:30 samples of Sjogren’s syndrome labial glands,18 samples of acute inflammatory labial glands and 30 samples of normal labial glands were collected and scanned by confocal Raman micro-spectrometer.The methods of principal com-ponent analysis (PCA)and discrimination function analysis (DFA)were employed to analyze the spectral data and dis-criminate the different tissues.Results:Differences were discovered between in the Raman spectra of various labial gland tissues,which were assigned to biomolecules such as proteins,nucleic acids and lipids.The accuracy of discrimination carried out by PCA-DFA reached 91.8% and the accuracy of cross-validaiton was 89.4%.Conclusion:The differences existing in Raman spectra of labial glands could not only reflect the biomolecular alterations but also diagnose the labial gland diseases.Raman spectroscopy had the potential to be utilized in the clinical diagnosis.关键词
唇腺/炎性病变/拉曼光谱/诊断Key words
lip gland/inflammatory lesions/Raman spectroscopy/diagnosis分类
化学化工引用本文复制引用
薛丽丽,骆献阳,蔡巧玲,孙佩,陈培琼,闫冰..唇腺炎性病变组织的共聚焦显微拉曼光谱特征研究[J].激光生物学报,2015,(1):95-99,5.基金项目
厦门市科技计划项目 （）
