井冈山大学学报（自然科学版）Issue(3)：84-89,6.DOI:10.3969/j.issn.1674-8085.2015.03.017
厚朴叶与厚朴皮、厚朴花的毒性比较研究
A COMPARATIVE TOXICITY STUDY OF THE LEAVES, BARKS AND FLOWERS OFMAGNOLIA OFFICINALIS
摘要
Abstract
Objective:To compare the toxicity of the leaves, barks and flowers ofMagnolia officinalis, and afford experimental basis for the development and utilization of its leaves.Methods: Through the acute toxicity experiment, mouse bone marrow micro nuclear test, mouse sperm malformation test and 30 days feeding experiment of rat, the comparative toxicity of different parts ofM. officinalis was investigated.Results: In the experiment of acute toxicity, mice were not dead. In the mouse bone marrow micro nuclear test and mouse sperm malformation test, there were no statistical differences between administration group and normal group. In 30 d feeding experiment of rat, rat food utilization, renal function and routine blood were affected, it was same as the coefficients of the liver, ovaries and testes. But in histologic examination of various organs of rats, there were no obvious abnormalities. In 30 d feeding experiment of rat, the barks and flowers did not affect the routine blood, but it was contrary for the leaves.Conclusion: The leaves ofM. officinalis had no acute toxicity, mutagenic toxicity and deformity toxicity, but have chronic toxicity. Its chronic toxicity affected food utilization, blood, kidney function and organ development. The difference among different parts ofM. officinalis was that the leavesaffected the routine blood, the others didn’t.关键词
厚朴叶/厚朴皮/厚朴花/毒性比较Key words
Magnolia officinalis leaf/Magnolia officinalis bark/Magnolia officinalis flower/toxicity comparision分类
医药卫生引用本文复制引用
徐文慧,黄玉珊,王霞,孙朝越,胡存华,周细根,赖斌,赖丹..厚朴叶与厚朴皮、厚朴花的毒性比较研究[J].井冈山大学学报（自然科学版）,2015,(3):84-89,6.基金项目
国家科技支撑计划项目子课题项目（2012BAC11B02-6）；井冈山大学2013年大学生创新实验项目 （）
