江汉大学学报（自然科学版）Issue(2)：64-69,6.
Sorafenib联合重组人可溶性TRAIL蛋白对K562细胞增殖抑制和凋亡诱导的研究
Sorafenib Combined with Recombinant Human TRAIL on Growth Inhibition Effects and Inducing Apoptosis of Leukemia Cells of K562
摘要
Abstract
Abatract: Objective To investigate the different effect of Sorafenib and TRAIL on proliferation inhibition and apoptosis inducing of K562 cells. Methods Inhibition of K562 cells proliferation by Sorafenib alone and combined with TRAIL were studied in vitro using CCK-8. Apoptosis induc-ing rate of K562 cells by Sorafenib alone and combined with TRAIL were accessed by Western-Blot detection. Results Combination with Sorafenib and TRAIL synergistically increased the growth inhibition effects and enhanced the apoptosis rate of K562 cells. Conclusion Combination treat-ment of Sorafenib and TRAIL showed a synergistic anti-proliferative effect in K562 cells.关键词
索拉非尼/TRAIL/白血病细胞/细胞增殖抑制/细胞凋亡Key words
Sorafenib/TRAIL/leukemia cells of K562/proliferation inhibition/cell apoptosis分类
医药卫生引用本文复制引用
王阿慧,凌艳英,庄秋容,邓家德..Sorafenib联合重组人可溶性TRAIL蛋白对K562细胞增殖抑制和凋亡诱导的研究[J].江汉大学学报（自然科学版）,2014,(2):64-69,6.基金项目
广州市医药卫生科技项目 （）
