摘要
Abstract
Objective To study the significance of the variations of serum neuron specific enolase (NSE) level in hypox-ic-ischemic encephalopathy (HIE) neonatorum. Methods The serum NSE level were detected in 75 asphyxia neonato-rum (asphyxia group) and 20 normal neonatomm (control group) by the method of ELISA after parturition 1,3 and 7 days. The relation of serum NSE level and hypoxic ischemic encephalopathy was analyzed. Results After parturition 1,3 and 7 days,the serum NSE level in asphyxia group was higher than that in control group [(44.50±12.08)μg/Lvs (15.59±6.25)μg/L,(42.65±12.43) μg/L vs (15.38±5.84) μg/L,(37.90±9.50) μg/L vs (13.92±5.37) μg/L],there had significant difference (P<0.05).The serum NSE level in sever asphyxia group was higher than that in mild asphyxia group [(58.95±14.85)μg/Lvs (29.15±9.32) μg/L, (62.95±19.13) μg/Lvs ( 22.35±5.75) μg/L, (57.35±13.75) μg/Lvs (18.45±5.25) μg/L],there had significant difference (P<0.05).After parturition 1,3 and 7 d,the serum NSE level in HIE neonatorum(19 cases) was in-creased and in MRI normal neonatorum (56 cases) was decreased,the serum NSE level in HIE neonatorum was higher than that in MRI normal neonatorum [(59.84±15.09) μg/Lvs (32.95±12.86)μg/L,(63.95±19.21)μg/Lvs (25.73±6.75)μg/L, (68.25±19.79) μg/L vs (19.62±5.94) μg/L],there had significant difference (P<0.05). Conclusion The variations of serum NSE level can be the important indicator to monitor HIE in asphyxia neonatorum.关键词
窒息,新生儿/缺氧缺血性脑病/神经元特异性烯醇化酶Key words
Asphyxia neonatorum/Hypoxic-ischemic encephalopathy/Neuron-specific enolase分类
医药卫生
