摘要
Abstract
Objective To explore the effect and safety of de-escalation therapy of glucocorticoids in the treatment of neurodermatitis. Methods By randomized controlled open labeled trial,the selected 160 patients were evenly divided into 4 groups in random.The de-escalation therapy was adopted in experimental group.To be specific,compound flumethasone ointment was externally used once respectively each morning and evening in the first week.The desonide cream was selected for replacement once a day in the second week.In the third week,etofesalamide ointment was ap-plied in place of desonide cream twice a day,one in the morning and the other in the evening.The control group was further divided into group A,group B,and group C.They were only provided with compound flumetasone ointment,des-onide cream,and etofesalamide ointment respectively for consecutive 3 weeks.The clinical effects before medication,1st, 2nd,and 3rd weeks after therapy were observed. Results The clinical effect in experimental group was tantamount to that in group A,but was superior to that in both group B and group C.Occurrence of adverse reactions in the experimen-tal group was lower than that in group A,but there was no significant difference in comparison with that in group B or group C. Conclusion Application of de-escalation therapy in treating neurodermatitis has advantages of good effect,few adverse reactions,and low recurrence rate.关键词
神经性皮炎/糖皮质激素/降阶梯疗法/效果Key words
Neurodermatitis/Glucocorticoid/De-escalation therapy/Effect分类
医药卫生
