摘要
Abstract
Objective To analyze the difference of expression level of fibrosis indexes between blood stasis syndrome and none-blood stasis syndrome in diabetic nephropathy (DN) to verify the theory of traditional Chinese medicine (TCM) that"blood stasis is the main pathogenesis of renal fibrosis in DN". Methods According to syndrome differenti-ation of TCM,60 patients with DN in our hospital were divided into the blood stasis syndrome group (the group A) and the none-blood stasis syndrome group (the group B),another healthy control group (the group C) was set up,fibrosis re-lated indicators of all samples were tested,and the data was analyzed. Results All DN patients’serum HA,PCⅢ,TIMP-1 were higher than those the healthy control group (P<0.01),The difference of TIMP-1 level between between the blood stasis syndrome and the blood stasis syndrome group was significant (P<0.01). Conclusion The degree of fibrosis was heavy in blood stasis syndrome group of DN,it matches with the theory that "blood stasis is the main pathogenesis of renal fibrosis in DN".关键词
糖尿病肾病/肾纤维化/血瘀证/人基质金属蛋白酶组织抑制因子-1Key words
Diabetic nephropathy/Renal fibrosis/Blood stasis syndrome/Tissue inhibitors to metalloproteinase-1分类
医药卫生
