中国当代医药Issue(22)：26-28,3.
妊娠期糖尿病患者胎盘组织中IRS-1和GLUT4的表达
Expression of IRS-1,GLUT4 in placenta of patients with gestational dia-betes mellitus
摘要
Abstract
Objective To explore the Expression of IRS-1,GLUT4 in placenta of patients with gestational diabetes mellitus. Methods 83 pregnant women treated in outpatient department in ourhosptal from March 2012 to March 2014 obstetric outpatient were selected and the gestational diabetes mellitus (GDM) group (n=43)and the The normal full-term pregnancy group (the control group) (n=40) according to examination results.Different clinical indicators (height, blood pressure,weight,and fasting blood glucose, fasting insulin,total cholesterol,triglyceride,etc.), in the two groups were detected,expression level of IRS-1 and GLUT4 of placenta in patients were determined by reverse transcription poly-merase chain reaction (RT-PCR) methods in the two groups. Results The level of fasting glucose,fasting insulin,total cholesterol,and triglycerides and so on in the GDM group were higher than those in the control group (P<0.05).HOMA-IR of the GDM group was higher than that in the control group,HOMA-ISI,HOMA-β% the GDM group was lower than that in the control group (P<0.05).There was a statistical difference of IRS-1 expression level of placenta in the two groups (P<0.05);there was no statistical difference of GLUT4 expression level of cytoplasm in placenta of the two groups (P>0.05),there was a statistical difference of GLUT4 expression level of Cell membrane in placenta of the two groups (P<0.05). Conclusion As a signal transduction molecule in the insulin signaling pathway,IRS-1,GLUT4 can play an im-portant role in insulin resistance.关键词
妊娠期糖尿病/胰岛素受体底物-1/葡萄糖转运蛋白4/胰岛素Key words
Gestational diabetes mellitus/Insulin receptor substrate-1/Glucose transporter 4/Insulin分类
医药卫生引用本文复制引用
曹聪明,丁红涛,李妙荣,孙晓海..妊娠期糖尿病患者胎盘组织中IRS-1和GLUT4的表达[J].中国当代医药,2014,(22):26-28,3.基金项目
原卫生部医药卫生科技项目 （）
