摘要
Abstract
Objective To discuss clinical effect on different doses of mifepristone in the treatment of uterine fibroid. Methods 85 patients with uterine fibroid from January 2013 to February 2014 in our hospital were collected and ran-domly divided into observation group(42 cases)and control group(43 cases).Mifepristone tablet 12.5 mg was used in con-trol group,mifepristone tablet 25 mg was used in observation group.The clinical effect,size of uterine fibroid,incidence rate of adverse reaction and serum FSH,LH,E2,P in two groups was compared respectively. Results The total effective rate of observation group was 95.24%,significantly higher than that of control group (83.72%),with statistical difference (P<0.05).After treatment,size of uterine fibroid in two groups was obviously less than before treatment respectively,with statistical difference(P<0.05).After treatment,size of uterine fibroid in two groups was compared,with no statistical differ-ence(P>0.05).The serum FSH,LH,E2,P level in two groups was compared respectively before and after treatment,with statistical difference (P<0.05).After treatment,the serum FSH,LH,E2,P level in observation group was obviously lower than that in control group respectively(P<0.05).Incidence rate of adverse reaction in observation group was 21.43%,ob-viously higher than that in control group (9.30%),with statistical difference (P<0.05). Conclusion 25 mg/(time·d) is the effective dose of mifepristone in the treatment of uterine fibroid,can improve the clinical efficacy,but the incidence rate of adverse reaction is higher than that low dose group.关键词
不同剂量/米非司酮/子宫肌瘤/治疗Key words
Different doses/Mifepristone/Uterine fibroid/Treatment分类
医药卫生
