摘要
Abstract
Objective To evaluate the clinical efficiency of paroxetine combined with quetiapine in treating obsessive-compulsive disorder. Methods 60 patients with obsessive-compulsive disorder were randomly divided into study group and control group,30 cases in each group.Paroxetine and quetiapine were given to the study group,while only paroxetine was given to the control group,the treatment course were 8 weeks.Yale-Brown obsessive compulsive scale (Y-BOCS), Hamilton depression scale (HAMD),Hamilton anxiety scale(HAMA) were used before treatment and after 2,4,6,8 weeks treatment to assess the efficacy,treatment emergent symptom scale (TESS) was used to assess the side effects. Results The total effective rate of observation group was higher than that of control group,the difference was significant (P<0.05).At the end of treatment,the Y-BOCS,HAMD,HAMA score of two groups were decreased (P<0.05 or 0.01),while after 6 weeks treat-ment,Y-BOCS,HAMD,HAMA scores between the two groups had significant difference (P<0.05). Conclusion Paroxetine combined with quetiapine in treatment of obsessive-compulsive disorder can improve therapeutic efficacy,the security is better,not increase adverse reactions.关键词
帕罗西汀/喹硫平/强迫症Key words
Paroxetine/Quetiapine/Obsessive-compulsive disorder分类
医药卫生
