中国当代医药Issue(31)：12-14,3.
脑损伤后神经细胞凋亡变化及黄体酮保护作用的研究
Study of the change of nerve cell apoptosis after traumatic brain injury and protective role of progesterone
摘要
Abstract
Objective To investigate the change of nerve cell apoptosis after traumatic brain injury and protective role of progesterone. Methods Male Spraque-Dawley rats were randomly divided into the sham-operated group,the brain damage group and the progesterone (PROG) treatment group.Improved Feeney free fall injury apparatus was used to es-tablish the brain injury model in rats.The rats were killed respectively after 24,48,72 injury.The changes of the positive cell number of Caspase-3 in the cortex and hippocampus CA1 were examined by immunohistochemistry. Results The positive cell numbers of Caspase-3 of the brain damage group were increased. The positive cell numbers of Caspase-3 in the PROG treatment group were distinctly fewer than those of the brain damage group (P<0.05). Conclusion PROG inhibiting the expression of Caspase-3 after brain injury, may be one of the protective mechanisms of brain injury of PROG.关键词
黄体酮/脑损伤/半胱氨酸天冬氨酸蛋白酶-3Key words
Progesterone/Traumatic brain injury/Cysteine aspartic acid protease-3引用本文复制引用
张于,司道文,李云,裴斐,周洪霞,徐胜,董伟,张立民,杨鹏,张宇新..脑损伤后神经细胞凋亡变化及黄体酮保护作用的研究[J].中国当代医药,2014,(31):12-14,3.基金项目
河北省教育厅科学研究计划项目（Z2011168）；河北省唐山市科学技术研究与发展计划项目 （）
