中国当代医药Issue(35)：131-132,137,3.
非小细胞肺癌患者EGFR检测的临床意义分析
Analysis of clinical significance on EGFR detection in patients with non-small cell lung cancer
农巧红 1申东兰 1牟尚东1
作者信息
- 1. 北京大学深圳医院肿瘤内科，深圳 518036
- 折叠
摘要
Abstract
Objective To investigate clinical significance on epidermal growth factor receptor(EGFR)of peripheral blood in patients with non-small cell lung cancer (NSCLC). Methods Clinical data of 49 patients pathologically confirmed with NSCLC were retrospectively analysed.High-throughput sequencing were used to detect EGFR mutation state in all patients’ peripheral blood.The relationship between whether EGFR mutation and sex,age,smoking history,pathological type and pathological stage,condition after drug treatment were analysed. Results EGFR mutation rate of different gen-der,age group was compared respectively,with no statistical difference (P>0.05).EGFR mutation rate in smoking group was higher than that in non-smoking group (P<0.05).EGFR mutation rate of different pathological type and pathological stage was compared respectively,with statistical difference(P<0.05).The progress rate of EGFR non-mutation group after taking was higher than that of EGFR mutant group,with statistical difference (P<0.01). Conclusion EGFR mutation is not associated with sex and age,is related to smoking,pathological type and pathological stage.The curative effect of pa-tients with EGFR mutation is better than that non-mutation after taking the drug.关键词
非小细胞肺癌/外周血EGFR/突变/临床意义Key words
Non-small cell lung cancer/Epidermal growth factor receptor of peripheral blood/Mutation/Clinical signifi-cance分类
医药卫生引用本文复制引用
农巧红,申东兰,牟尚东..非小细胞肺癌患者EGFR检测的临床意义分析[J].中国当代医药,2014,(35):131-132,137,3.
