摘要
Abstract
Objective To investigate the effectiveness and safety of the homemade octreotide combined with ulinastatin in the treatment of acute pancreatitis in order to accumulate experience for clinical medication and treatment of acute pancreatitis. Methods 187 patients with acute pancreatitis treated in our hospital from January 2011 to December 2013 were selected as the research objects and they were divided into the control group (n=94) and observation group (n=93) according to the random sampling of lottery law after admission.The control group was given subcutaneous injection of oc-treotide,0.1 mg/time,twice a day,while the observation group was treated with ulinastatin intravenous infusion,100 000 U/time, once a day on the basis of the treatment of control group.The improvement of clinical indicators (alleviation time of ab-dominal distension,abdominal tenderness and recovery time of blood amylase,urine amylase returning to normal) and APACHE II score in the two groups were compared.The total effective rate,incidence rate of severe complications,the fatality rate,the incidence rate of adverse reactions in the two groups were compared. Results The improvement time of the clinical indicators of the observation group was shorter than that of the control group (P<0.05) and the APACHE IIscore was lower than that of the control group (P<0.05).The total effective rate in the observation group was significantly higher than that of the control group (92.5%v s 77.6%,χ2=8.06,P=0.007).The incidence rate of severe complications was significantly lower than that of control group (4.3% vs 14.9%,χ2=6.03,P=0.023).The incidence rate of adverse reaction was higher than that of the control group (5.4% vs 3.2%),but the difference was not statistically significant (χ2=0.545, P=0.497). Conclusion Homemade octreotide combined with ulinastatin can effectively improve the related clinical indi-cators of the patients with acute pancreatitis and its effective rate is significantly higher than that of only one kind of medicine and the safety was high.It is worthy of clinical promotion and application.关键词
急性胰腺炎/奥曲肽/乌司他丁/临床效果Key words
Acute pancreatitis/Octreotide/Ulinastatin/Clinical effect分类
医药卫生
