摘要
Abstract
Objective To investigate the clinical effect and safety of penehyclidine hydrochloride treating acute organophosphorus pesticide poisoning (AOPP). Methods 120 cases with AOPP were randomly divided into the two groups.The observation group (n=60) was given penehyclidine hydrochloride,and the control group was given atropine. The detoxifying effect and the incidence rate of adverse reaction in the two groups were compared. Results The total ef-fective rate of the observation group was 93.33%,while the control group was 80.00%,the curative effect of the observa-tion group was obviously better than that in the control group (P<0.05);the muscarinic-like symptom duration was (1.70±0.45) h,nicotine-like symptom duration was (6.38±2.09) h,and duration of symptom of central nervous system was (12.50±3.22) h in the observation group,above-mentioned indicators in the observation was significantly shorter than that in the control group respectively [(2.31±0.52),(10.25±4.88),(18.37±3.16) h] (P<0.05);the disturbance consciousness recovery time was (23.46±11.30) h,ChE activity recovery time was (46.81±13.27) h and hospital stay was (7.03±2.85) d in the obser-vation group,above-mentioned indicators in the observation group was significantly shorter than that in the control group respectively [(40.58±12.35)h, (63.50±18.94)h,(11.52±3.06)d] (P<0.05);the incidence rate of heartbeat tachycardia, agitation,blurred vision,retention of urine and so on in the observation group was lower than that in the control group re-spectively (P<0.05). Conclusion Penehyclidine hydrochloride used in rescuing AOPP is safer and more effective.关键词
急性有机磷农药中毒/盐酸戊乙奎醚/阿托品/不良反应Key words
Acute organophosphorus pesticide poisoning/Penehyclidine hydrochloride/Atropine/Adverse reaction分类
医药卫生
