中国当代医药Issue(2)：4-6,3.
小鼠最大灌胃量的研究
Study on the maximum tolerant dosage of mice by gastric perfusion
摘要
Abstract
Objective To study the maximum tolerant dosage of mice by gastric perfusion and examine the influence of the electrocardiogram and myocardial tissue. Methods The maximum capacity was determined by using different body weight of mice after gastric perfusion.PEG6000 solution with different viscosity was prepared,and the T wave changes in ECG were recorded after administrating various dosages by gastric perfusion.The pathological sections of myocardial tissue was prepared and observed by using light and electron microscopy. Results In a certain weight range,linear rela-tionship exists between the weight of mice and the gastric volume.Compared with the blank group,T wave changes of ECG in mice after gastric perfusion with 20 g/ml and 40 g/ml PEG6000 solutions had no statistical difference (P>0.05), and myocardial tissue sections in mice showed no abnormalities. Conclusion Maximum intragastric volume of mice can be calculated according to the linear relationship;It has no effect of ECG and myocardial tissue with the greatest amount of intragastic gavage in a certain solution viscosity range.关键词
小鼠/灌胃/最大耐受剂量Key words
Mice/Gastric perfusion/Maximum tolerant dosage分类
医药卫生引用本文复制引用
鄢海燕,邹纯才,杨洋,李萍,邓小阳..小鼠最大灌胃量的研究[J].中国当代医药,2015,(2):4-6,3.基金项目
国家级大学生创新创业训练计划项目（201310368042）；安徽省科技攻关项目 （）
