摘要
Abstract
Objective To explore the influence of bile acid in patients with intrahepatic cholestasis of pregnancy on neonatal complications and prognosis. Methods 68 cases of pregnant women with intrahepatic cholestasis of pregnancy in our hospital from January 2012 to January 2014 were selected as intrahepatic cholestasis of pregnancy group,68 nor-mal pregnant women at the same time were selected as healthy control group.The bile acid,alanine aminotransferase, neonates with gestational age,neonatal birth quality and the incidence of fetal distress of the two groups was observed and compared. Results The level of bile acid and alanine aminotransferase in the intrahepatic cholestasis of pregnancy group was higher than that in the healthy control group,the difference was significance (t=13.0045,P=0.0000;t=7.2784, P=0.0000).The level of neonates with gestational age and neonatal birth quality in the intrahepatic cholestasis of preg-nancy group was lower than that in the healthy control group,the difference was significant (t=21.1026,P=0.0000;t=16.6681,P=0.0000).The incidence of fetal distress in the intrahepatic cholestasis of pregnancy group was higher than that in the healthy control group,the difference was significant (χ²=4.1676,P=0.0412). Conclusion The bile acid level of pregnant women with intrahepatic cholestasis of pregnancy increases significantly,which can lead to higher incidence of intrauterine distress,neonatal has shorter gestational age and lower birth quality,the overall prognosis is poor.关键词
妊娠期肝内胆汁淤积症/胆汁酸/新生儿预后Key words
Intrahepatic cholestasis of pregnancy/Bile acid/Neonatal prognosis分类
医药卫生
