摘要
Abstract
Objective To discuss the influence of the combined treatment of gonadotropin releasing hormone analogue (GnRHa) and recombinant human growth hormone (rhGH) on height and the development of bone age of idiopathic cen-tral precocious puberty (ICPP) in girls. Methods 60 girls with ICPP treated in our hospital were selected as the research object,and according to the random digital table method,they were divided into the single drug group and the combina-tion drug group,there were 30 cases in each group.The single drug group only was given GnRHa,while the combination drug group was given rhGH on the basis of the single drug group,height and change of bone age in the two groups were compared. Results In the single drug group and the combination drug group after treatment,prediction adult height was increased (3.93±1.01) cm and (7.77±1.95) cm respectively,and the difference was statistically significant (t=5.3643, P=0.0008);the single drug group and the combination drug group compared with those before treatment,HtSDSBA increased obviously (t=6.1397, P=0.0007;t=9.7936,P=0.0003);in the combination drug group,HtSDSBA increased more significantly than that in the single drug group (t=5.8396, P=0.0007);the growth speed of combination drug group was significantly faster than the single drug group (t=9.9873, P=0.0002);and there were no obvious adverse reaction in the two group. Conclusion GnRHa combined with rhGH can obviously improve the prediction adult height and HtSDSBA,and it had no significant effect on the development of bone age,recent medication is more safe.关键词
促性腺激素释放激素类似物/重组人生长激素/特发性中枢性性早熟/身高标准差分值Key words
Gonadotropin releasing hormone analogue/Recombinant human growth hormone/Idiopathic central preco-cious puberty/HtSDSBA分类
医药卫生
