中国当代医药Issue(3)：138-140,3.
解氏肾癌一号方对小鼠肾癌的抑制作用及对Bcl-2和Bax蛋白表达的影响
Inhibitory effect and affect on Bcl-2 and Bax protein expression of renal cancer prescription No.1 in mice with renal cancer
朱成功 1崔佳 1赵莹莹 2解建国2
作者信息
- 1. 大连医科大学附属第二医院肿瘤科，大连 116031
- 2. 大连市中心医院中医科，大连 116044
- 折叠
摘要
Abstract
Objective To investigate inhibitory effect and affect on Bcl-2 and Bax protein expression of renal cancer prescription No.1 in mice with renal cancer. Methods The animal models of renal cancer were established and divided into saline control group,Chinese medicine control group,interleukin-2 group and renal cancer prescription NO.1 group. Inhibitory rate of tumor in four groups was calculated and the apoptosis-related protein Bcl-2 and Bax index were de-tected by immuno- histochemistry. Results The inhibitory rate of tumor in renal cancer prescription NO.1 group was higher than that in saline control group and interleukin-2 group respectively,and the weight of mice was increased.The expression of Bcl-2 in renal cancer prescription NO.1 group was lower,but expression of Bax in renal cancer prescrip-tion NO.1 group was higher. Conclusion Renal cancer prescription NO.1 can inhibit the expression of Bcl-2,raise the expression of Bax,and suppress tumor growth,improve the quality of life in mice.关键词
肾癌/Bcl-2/Bax/细胞凋亡Key words
Renal cancer/Bcl-2/Bax/Apoptosis分类
医药卫生引用本文复制引用
朱成功,崔佳,赵莹莹,解建国..解氏肾癌一号方对小鼠肾癌的抑制作用及对Bcl-2和Bax蛋白表达的影响[J].中国当代医药,2015,(3):138-140,3.
