中国当代医药Issue(7)：40-43,4.
不同剂量他汀对急性非ST段抬高心肌梗死患者介入术后肾功能的影响
The influence of different dose of statins on postoperative renal function in patients with acute non-ST segment elevation myocardial infarction
摘要
Abstract
Objective To evaluate the influence of different dose of statins on postoperative renal function in patients with acute non-ST segment elevation myocardial infarction. Methods 116 patients diagnosed as acute non-ST segment elevation myocardial infarction in our hospital heart center from December 2010 to November 2010 were selected,and all patients were agreed to undergo interventional examination and treatment.116 patients were randomly divided into 20 mg normal dose group and 40 mg strengthened dose group.All patients were given with atorvastatin calcium tablet oral before going to sleep.After three days of standard drug therapy,they were undergone interventional examination and treatment.All patients wre drew blood on preoperative and postoperative 24 hours,48 hours for the test of creatinine (SCr),urea nitrogen (BUN),cystatinC (Cys C) and C-reactive protein (CRP).According to the test results calculated the endogenous creatinine clearance (CCr). Results Compared with strengthened dose group,the Cys C level of the normal dose group at postoperative 24 hours was hihger (P<0.05),CCr was lower (P<0.05).Compared with preoperative level,Cys C level of normal dose group at postoperative 24 hours was higher (P<0.05). Conclusion Interventional examination and treatment with the contrast medium can lead to glomerular filtration function damage.The larger dose of statins can more effectively improve the kidney function.Application of 40 mg atorvastatin can be more effective prevented the happening of the CI-AKI than 20 mg atorvastatin.关键词
对比剂导致的急性肾损伤/介入治疗/肾功能/C反应蛋白Key words
Contrast-induced acute kidney injury/Interventional therapy/Renal function/C-reactive protein分类
医药卫生引用本文复制引用
段娜,侯爱洁,李占全..不同剂量他汀对急性非ST段抬高心肌梗死患者介入术后肾功能的影响[J].中国当代医药,2015,(7):40-43,4.基金项目
辽宁省自然科学基金项目计划 （）
