中国当代医药Issue(9)：32-34,3.
血浆降钙素原监测指导肝硬化合并自发性细菌性腹膜炎治疗的临床效果研究
Clinical effect study on plasma procalcitonin monitoring in the guidance of treatment of liver cirrhosis combined with spontaneous bacterial peri-tonitis
摘要
Abstract
Objective To explore the guiding significance of procalcitonin (PCT) in the antibiotic therapy in patients with liver cirrhosis and spontaneous bacterial peritonitis(SBP). Methods Ninety-six patients diagnosed as liver cirrhosis combined with SBP accepted treatment in our department of gastroenterology from January 2012 to December 2014 were selected as research objects and evenly divided into PCT group and control group in random,each group of 48 cases.On the basis of the same conventional treatment,initial use,dose,and stopped use of antibiotics determined by PCT level were applied in PCT group.In the control group,use of antibiotic was determined by clinical experience and pa-tient’s symptoms.The PCT level in the process of treatment was observed as well as curative effect,course of treatment in antibiotic and its cost,hospital stay and hospitalization expense. Results From the first day of admission to being dis-charged from hospital,PCT level gradually decreased in the survived cases in both groups,while the PCT level in death cases gradually increased.There were statistical difference with PCT level in the 7th and 10th days of admission in sur-vived cases between two groups(P<0.01).On being discharged from hospital,PCT level between two groups didn’t display statistical difference(P>0.05).There was no statistical difference in curative effect in these survived patients between two groups (P>0.05).The course of treatment,hospital stay in PCT group was shorter than that in control group respectively, cost of antibiotics and hospitalization expense in PCT group was less than that in control group respectively,with statis-tical difference (P<0.05). Conclusion Liver cirrhosis combined with SBP guided by PCT for antibiotic therapy can re-duce the usage of antibiotics,shorten patient’s hospital stay and decrease cost.关键词
降钙素原/肝硬化/自发性细菌性腹膜炎/抗菌治疗Key words
Procalcitonin/Liver cirrhosis/Spontaneous bacterial peritonitis/Antibiotic therapy分类
医药卫生引用本文复制引用
左彦,张允健,陈远博,雷平光..血浆降钙素原监测指导肝硬化合并自发性细菌性腹膜炎治疗的临床效果研究[J].中国当代医药,2015,(9):32-34,3.基金项目
广东省深圳市宝安区科技计划项目 （）
