李荣岗 1陈兰花 2孙丽霞 2廖悦华 2刘琼茹 2余卫东1
作者信息
- 1. 中山大学附属江门医院 广东省江门市中心医院病理科，广东江门 529030
- 2. 广东省江门市人民医院病理科，广东江门 529030
- 折叠
摘要
Abstract
Objective To study the clinicopathological characteristics and prognosis of small cell carcinoma of the cervix (SCCC). Methods 26 cases of patients with SCCC were selected,the clinical and pathological date was retrospec-tively analyzed,the clinicopathological characteristics and prognosis was analyzed. Results In 26 cases of patients,24 patients presented with symptoms of abnormal vaginal bleeding or postcoital spotting,2 patients presented with irregular menstruation,atypical cells were found through cervical liquid thin-layer cytology examination in 15 patients for physi-cal examination.In 26 patients,10 patients were stage ⅠB1,8 patients were stage ⅠB2,2 patients were stage IIA2,4 patients were stageⅢB and 2 patients were stageⅣB.Histological features showed that,tumor cells were irregular nests patchy distribution,size and shape of tumor cell was consistent,short round or spindle,cytoplasm was less,nuclear hyper-chromatism,nucleoli was lack and nuclear fission like see was more,of which,2 cases of merger moderately fifferentiated adenocarcinoma,2 cases of merger cervical high-grade intraepithelial neoplasia (CIN)Ⅲ.26 patients were all taken with immunohistochemical staining,the positive rate of cytokeratin (CK) was 100%,of epithelial membrane antigen (EMA) was 84.6%,of neuron specific enolose (NSE) was 100%,of synaptophysin (Syn) was 92.3%,of CD56 was 92.3%,of Chro-mogranin A (CgA) was 69.2%,of TTF1 was 7.7%,of Ki67 was 70%~90%. Conclusion SCCC is rare relatively,and has no special clinical manifestation,morphologically,it is similar to small cell cancer of lung,immunohistochemisty,tumor cells express neuroendocrine markers,recurrence and metastasis can be found in most patients early,and high malignant degree and poor prognosis.关键词
宫颈肿瘤/小细胞癌/临床病理特征/免疫组织化学/预后Key words
Cervix neoplasms/Small cell carcinoma/Clinicopathological characteristics/Immunohistochemistry/Prognosis分类
医药卫生
