摘要
Abstract
Objective To observe the change of soluble ST2(sST2)and NT-proBNP in heart failure and estimated value of short-term prognosis. Methods 52 patients with heart failure admitted into our hospital from October 2012 to August 2014 were selected as diseased group.Another 52 participants for healthy physical examinations in the same period were classified into healthy control group.The level of plasma sST2 on admission was measured by enzyme linked im-munosorbent assay(ELISA),and the level of NT-proBNP was tested colloidal gold method.The differences of two indexes were compared in different levels of cardiac function. Results According to New York Heart Association (NYHA)grad-ing,the higher the grading was,the higher the measured values of sST2 and NT-proBNP were,the higher the grading was,the lower the measured value of LVEF was,which displayed statistical difference (P<0.05).The level of sST2 and NT-proBNP in diseased group was obviously higher than that in healthy control group respectively,with statistical dif-ference(P<0.05).The level of LVEF in diseased group was much lower than that in healthy control group,with a statisti-cal difference(P<0.05).Two markers of sST2 and NT-proBNP had negative correlations with LVEF(P<0.01),but indicated statistically positive correlation with NYHA grading (P<0.01).Logistic regression analysis showed that NT-proBNP and ST2 were two independent predictive factors in short-term prognosis of heart failure (P<0.01). Conclusion Test of sST2 and NT-proBNP level may have some clinical significance in differential diagnosis and short-term prognosis evaluation of heart failure in different degree.关键词
可溶性ST2/NT-proBNP/心力衰竭/预后Key words
Soluble ST2/NT-proBNP/Heart failure/Prognosis分类
医药卫生
