中国当代医药Issue(10)：103-105,108,4.
血清趋化素，hs-CRP与妊娠期糖尿病孕妇胰岛素抵抗的关系
Association of serum chemokine and high-sensitivity C-reactive protein level with insulin resistance in gestational diabetes mellitus
摘要
Abstract
Objective To investigate the association of serum chemokine and high-sensitivity C-reactive protein (hs-CRP)with insulin resistance(IR)in gestational diabetes mellitus (GDW). Methods The pregnant women examined regu-larly in the department of gynecology and obstetrics in our hospital from July 2012 to July 2014 were selected as study objects.According to the results of blood glucose screening,40 cases of the newly diagnosed pregnant women with dia-betes were randomly selected as group one,40 cases of pregnant women with GDM whose blood glucose was well con-trolled by controlling their diet and motion were randomly selected as group two and another 40 cases of pregnant women with normal glucose tolerance were selected as group three.The serum chemokine level in the pregnant women of each group were checked by using enzyme-linked immunosorbent assay.Determination of serum hs-CRP level of the pregnant women in each group was detected by immune transmission turbidimetry.The IR degree of the pregnant women in each group was valued by using HOMA insulin resistance index (HOMA-IRI).The serum chemokine,hs-CRP and HOMA-IR of the pregnant women among three groups were compared and analyzed. Results The correlation indexes of serum hs-CRP,chemokine and IR (FPG,FINS,HOMA-IRI)of the pregnant women in group one was significantly higher than that in other two groups respectively (P<0.05).The serum chemokine,hs-CRP related with IR index in group one were positively correlated (P<0.05),but in group three they were not related (P>0.05).The serum chemokine related with FINS and HOMA-IRI in group two was positively (P<0.05),and had no correlation with FPG (P>0.05).The hs-CRP and IR related indexes were positively correlated in group two(P<0.05). Conclusion The IR obviously exists in the pregnant women with GDM and the hs-CRP and serum chemokine in their body obviously increase.The mechanism of IR in pos-itive correlation plays an important role.关键词
妊娠期糖尿病/胰岛素抵抗/血清趋化素/超敏C反应蛋白Key words
Gestational diabetes mellitus/Insulin resistance/Serum chemokine/High-sensitivity C-reactive protein分类
医药卫生引用本文复制引用
张焕灵,门英华,张慧..血清趋化素，hs-CRP与妊娠期糖尿病孕妇胰岛素抵抗的关系[J].中国当代医药,2015,(10):103-105,108,4.基金项目
广东省深圳市南山区技术研发和创意设计项目分项资金教育（卫生）科技资助项目 （）
