摘要
Abstract
Objective To evaluate the effect of trimetazidine on treating unstable angina pectoris after percutaneous coronary intervention (PCI). Methods 100 patients with unstable angina pectoris undergone PCI in our hospital from January 2013 to January 2014 were selected,and were divided into experimental group (n=52) and control group (n=48) according to the random number table.Conventional drug therapy for coronary heart disease was provided to all patients. Administration of trimetazidine in regular dose 5 days before surgery was applied to experimental group.The level of CK-MB,cTnI,and MPV was tested by blood drawing before surgery,just after surgery,and 24 hours after surgery in the two groups. Results The efficiency rate and total effective rate of experimental group was 61.5% and 88.5%respective-ly,higher than 45.8% and 75.0% of control group,the difference was significant (P<0.05).The level of CK-MB and cTnI was increased just after surgery compared with that before surgery (P<0.05),and the control group increased more than that of experimental group (P<0.05).The level of CK-MB and cTnI decreased remarkably 24-hour after surgery com-pared with that just after surgery (P<0.05),and the experimental group was lower than that of control group (P<0.05).The level of MPV was increased just after surgery compared with that before surgery (P<0.05),and the control group in-creased more than that of experimental group (P<0.05);The level of MPV decreased to preoperative level 24-hour after surgery (P>0.05). Conclusion Oral administration of trimetazidine in regular dose can reduce myocardial injury caused by PCI and play a cardioprotective effect,and decrease the possibility of acute stent thrombosis.关键词
曲美他嗪/心绞痛/心肌损伤/经皮冠状动脉介入治疗Key words
Trimetazidine/Angina Pectoris/Myocardial injury/Percutaneous coronary intervention分类
医药卫生
